Hepatocellular adenoma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]


Hepatocellular adenoma was first described in 1958 by Edmondson as an encapsulated liver tumor that does not contain bile ducts. Baum reported the important relationship between oral contraceptive use and hepatocellular adenoma development in 1973. Edmondson, in 1976, published a case control study giving further evidence of this association.

Historical Perspective


  1. Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
  2. Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
  3. G. Klatskin (1977). "Hepatic tumors: possible relationship to use of oral contraceptives". Gastroenterology. 73 (2): 386–394. PMID 194813. Unknown parameter |month= ignored (help)
  4. J. K. Baum, J. J. Bookstein, F. Holtz & E. W. Klein (1973). "Possible association between benign hepatomas and oral contraceptives". Lancet (London, England). 2 (7835): 926–929. PMID 4126557. Unknown parameter |month= ignored (help)
  5. E. Horvath, K. Kovacs & R. C. Ross (1974). "Letter: Benign hepatoma in a young woman on contraceptive steroids". Lancet (London, England). 1 (7853): 357–358. PMID 4131203. Unknown parameter |month= ignored (help)
  6. H. A. Edmondson, B. Henderson & B. Benton (1976). "Liver-cell adenomas associated with use of oral contraceptives". The New England journal of medicine. 294 (9): 470–472. doi:10.1056/NEJM197602262940904. PMID 173996. Unknown parameter |month= ignored (help)

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