Hepatocellular adenoma MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Cafer Zorkun, M.D., Ph.D. [2] Zahir Ali Shaikh, MD[3]Sabawoon Mirwais, M.B.B.S, M.D.[4]


The MRI findings of hepatocellular adenoma range from hyperintense to mildly hypointense relative to the liver tissue on T1 weighted images. On T2 weighted images, the findings are predominantly hyperintense relative to the liver, whereas in the presence of necrosis and hemorrhage they can be heterogeneous with hyper- or hypo-attenuating signal. The central scar on gadolinium is not seen in hepatocellular adenoma. There is usually no significant uptake with injection of hepatocellular specific contrast agent, gadolinium benzoyloxy propionic tetraacetate (Gd-BOTA).



MRI showing multiple hepatocellular adenomas (yellow arrows). Case courtesy of Dr Chris O'Donnell, Radiopaedia.org, rID: 26904


  1. . doi:10.1594/ecr2013/C-2620. Missing or empty |title= (help)
  2. Dhingra, Sadhna; Fiel, M. Isabel (2014). "Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic Characteristics". Archives of Pathology & Laboratory Medicine. 138 (8): 1090–1097. doi:10.5858/arpa.2013-0183-RA. ISSN 0003-9985.
  3. Nault, Jean-Charles; Paradis, Valérie; Cherqui, Daniel; Vilgrain, Valérie; Zucman-Rossi, Jessica (2017). "Molecular classification of hepatocellular adenoma in clinical practice". Journal of Hepatology. 67 (5): 1074–1083. doi:10.1016/j.jhep.2017.07.009. ISSN 0168-8278.
  4. Maarten G. Thomeer, Mirelle Broker, Joanne Verheij, Michael Doukas, Turkan Terkivatan, Diederick Bijdevaate, Robert A. De Man, Adriaan Moelker & Jan N. IJzermans (2016). "Hepatocellular adenoma: when and how to treat? Update of current evidence". Therapeutic advances in gastroenterology. 9 (6): 898–912. doi:10.1177/1756283X16663882. PMID 27803743. Unknown parameter |month= ignored (help)
  5. L. Arrive, J. F. Flejou, V. Vilgrain, J. Belghiti, D. Najmark, M. Zins, Y. Menu, J. M. Tubiana & H. Nahum (1994). "Hepatic adenoma: MR findings in 51 pathologically proved lesions". Radiology. 193 (2): 507–512. doi:10.1148/radiology.193.2.7972769. PMID 7972769. Unknown parameter |month= ignored (help)
  6. Massimo Roncalli, Amedeo Sciarra & Luca Di Tommaso (2016). "Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma". Clinical and molecular hepatology. 22 (2): 199–211. doi:10.3350/cmh.2016.0101. PMID 27189732. Unknown parameter |month= ignored (help)
  7. Matthanja Bieze, Jacomina W. van den Esschert, C. Yung Nio, Joanne Verheij, Johannes B. Reitsma, Valeska Terpstra, Thomas M. van Gulik & Saffire S. K. S. Phoa (2012). "Diagnostic accuracy of MRI in differentiating hepatocellular adenoma from focal nodular hyperplasia: prospective study of the additional value of gadoxetate disodium". AJR. American journal of roentgenology. 199 (1): 26–34. doi:10.2214/AJR.11.7750. PMID 22733890. Unknown parameter |month= ignored (help)
  8. Andrei S. Purysko, Erick M. Remer, Christopher P. Coppa, Nancy A. Obuchowski, Erika Schneider & Joseph C. Veniero (2012). "Characteristics and distinguishing features of hepatocellular adenoma and focal nodular hyperplasia on gadoxetate disodium-enhanced MRI". AJR. American journal of roentgenology. 198 (1): 115–123. doi:10.2214/AJR.11.6836. PMID 22194486. Unknown parameter |month= ignored (help)
  9. Sheela Agarwal, Jorge M. Fuentes-Orrego, Thomas Arnason, Joseph Misdraji, Kartik S. Jhaveri, Mukesh Harisinghani & Peter F. Hahn (2014). "Inflammatory hepatocellular adenomas can mimic focal nodular hyperplasia on gadoxetic acid-enhanced MRI". AJR. American journal of roentgenology. 203 (4): W408–W414. doi:10.2214/AJR.13.12251. PMID 25055198. Unknown parameter |month= ignored (help)
  10. Maarten G. Thomeer, Francois E. Willemssen, Katharina K. Biermann, Haroun El Addouli, Rob A. de Man, Jan N. Ijzermans & Roy S. Dwarkasing (2014). "MRI features of inflammatory hepatocellular adenomas on hepatocyte phase imaging with liver-specific contrast agents". Journal of magnetic resonance imaging : JMRI. 39 (5): 1259–1264. doi:10.1002/jmri.24281. PMID 23897798. Unknown parameter |month= ignored (help)
  11. Heqing Wang, Chun Yang, Shengxiang Rao, Yuan Ji, Jing Han, Ruofan Sheng & Mengsu Zeng (2018). "MR imaging of hepatocellular adenomas on genotype-phenotype classification: A report from China". European journal of radiology. 100: 135–141. doi:10.1016/j.ejrad.2018.01.023. PMID 29496071. Unknown parameter |month= ignored (help)
  12. Dharmana, H.; Saravana-Bawan, S.; Girgis, S.; Low, G. (2017). "Hepatocellular adenoma: imaging review of the various molecular subtypes". Clinical Radiology. 72 (4): 276–285. doi:10.1016/j.crad.2016.12.020. ISSN 0009-9260.

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