Difference between revisions of "Teratoma classification"

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==Classification==
 
==Classification==
* '''Childhood Extracranial Germ Cell Tumors classification'''
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:* 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.<ref name="pmid6343221">{{cite journal| author=Dehner LP| title=Gonadal and extragonadal germ cell neoplasia of childhood. | journal=Hum Pathol | year= 1983 | volume= 14 | issue= 6 | pages= 493-511 | pmid=6343221 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6343221  }} </ref><ref name="pmid18381640">{{cite journal| author=McIntyre A, Gilbert D, Goddard N, Looijenga L, Shipley J| title=Genes, chromosomes and the development of testicular germ cell tumors of adolescents and adults. | journal=Genes Chromosomes Cancer | year= 2008 | volume= 47 | issue= 7 | pages= 547-57 | pmid=18381640 | doi=10.1002/gcc.20562 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18381640  }} </ref> Childhood extracranial GCTs can be divided into the following two types:
+
:Teratomas are classifiable based on different general characteristics and site of origin.
:::* Gonadal.
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:Historically teratomas was classified as :
:::* Extragonadal.
+
:* mature
:* 2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells.Childhood extracranial GCTs are broadly classified as the following:
+
:* immature
:::* Mature teratomas.
+
In adults teratomas likely demonstrate malignant inclination and behavior. In Children, different tumors from various origins are reported, while predominantly we may see sacrococcygeal tumors. We can also classify teratomas to benign and malignant tumors. The malignant types are named teratocarcinomas.  Based on site of origin, teratomas are generally arise from ovary, testicle, or tailbone and less commonly from other areas.<ref name="urlTeratomas: A Multimodality Review - ScienceDirect">{{cite web |url=https://www.sciencedirect.com/science/article/abs/pii/S0363018812000151?via%3Dihub |title=Teratomas: A Multimodality Review - ScienceDirect |format= |work= |accessdate=}}</ref>
:::* Immature teratomas.
 
:::* Malignant GCTs.
 
:* 3. GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types:
 
:::* Germinoma.
 
:::* Germinoma.
 
:::* Dysgerminoma (ovary).
 
:::* Seminoma (testis).
 
:::* Nongerminoma.
 
:::* Teratoma (mature and immature).
 
:::* Yolk sac tumor (endodermal sinus tumor).
 
:::* Choriocarcinoma.
 
:::* Embryonal carcinoma.
 
:::* Gonadoblastoma.
 
:::* Mixed GCT
 
:* 4. Pediatric GCT Biology
 
:* The following biologically distinct subtypes of GCTs are found in children and adolescents:
 
:::* Testicular GCTs.
 
:::* Ovarian GCTs.
 
:::* Extragonadal extracranial GCTs.
 
  
 
==References==
 
==References==
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[[Category:Pediatric cancers]]
 
[[Category:Pediatric cancers]]
 
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Revision as of 01:35, 16 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Masoud Bitarafan, M.D[[2]]

Classification

Teratomas are classifiable based on different general characteristics and site of origin.
Historically teratomas was classified as :
  • mature
  • immature

In adults teratomas likely demonstrate malignant inclination and behavior. In Children, different tumors from various origins are reported, while predominantly we may see sacrococcygeal tumors. We can also classify teratomas to benign and malignant tumors. The malignant types are named teratocarcinomas. Based on site of origin, teratomas are generally arise from ovary, testicle, or tailbone and less commonly from other areas.[1]

References

  1. "Teratomas: A Multimodality Review - ScienceDirect".

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