Difference between revisions of "Teratoma classification"

Jump to: navigation, search
(Classification)
(Classification)
Line 2: Line 2:
 
{{Teratoma}}
 
{{Teratoma}}
 
{{CMG}} {{AE}} {{MD}}
 
{{CMG}} {{AE}} {{MD}}
 +
 
==Classification==
 
==Classification==
 +
::* The World Health Organization has classified CNS GCTs into germinomas and the following nongerminomatous germ cell tumor (NGGCT) groups:<ref name="pmid9046301">{{cite journal| author=Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N et al.| title=Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. | journal=J Neurosurg | year= 1997 | volume= 86 | issue= 3 | pages= 446-55 | pmid=9046301 | doi=10.3171/jns.1997.86.3.0446 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9046301  }} </ref>
 +
:::* Choriocarcinoma.
 +
:::* Embryonal carcinoma.
 +
:::* Mixed germ cell tumor.
 +
:::* Teratoma.
 +
:::* Immature.
 +
:::* Mature.
 +
:::* Teratoma with malignant transformation.
 +
:::* Yolk sac tumor.
 
* '''Childhood Extracranial Germ Cell Tumors classification'''
 
* '''Childhood Extracranial Germ Cell Tumors classification'''
 
:* 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.<ref name="pmid6343221">{{cite journal| author=Dehner LP| title=Gonadal and extragonadal germ cell neoplasia of childhood. | journal=Hum Pathol | year= 1983 | volume= 14 | issue= 6 | pages= 493-511 | pmid=6343221 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6343221  }} </ref><ref name="pmid18381640">{{cite journal| author=McIntyre A, Gilbert D, Goddard N, Looijenga L, Shipley J| title=Genes, chromosomes and the development of testicular germ cell tumors of adolescents and adults. | journal=Genes Chromosomes Cancer | year= 2008 | volume= 47 | issue= 7 | pages= 547-57 | pmid=18381640 | doi=10.1002/gcc.20562 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18381640  }} </ref> Childhood extracranial GCTs can be divided into the following two types:
 
:* 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.<ref name="pmid6343221">{{cite journal| author=Dehner LP| title=Gonadal and extragonadal germ cell neoplasia of childhood. | journal=Hum Pathol | year= 1983 | volume= 14 | issue= 6 | pages= 493-511 | pmid=6343221 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6343221  }} </ref><ref name="pmid18381640">{{cite journal| author=McIntyre A, Gilbert D, Goddard N, Looijenga L, Shipley J| title=Genes, chromosomes and the development of testicular germ cell tumors of adolescents and adults. | journal=Genes Chromosomes Cancer | year= 2008 | volume= 47 | issue= 7 | pages= 547-57 | pmid=18381640 | doi=10.1002/gcc.20562 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18381640  }} </ref> Childhood extracranial GCTs can be divided into the following two types:

Revision as of 19:17, 19 August 2015

Teratoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Teratoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Staging

Laboratory Findings

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Teratoma classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Teratoma classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Teratoma classification

CDC on Teratoma classification

Teratoma classification in the news

Blogs on Teratoma classification

Directions to Hospitals Treating Teratoma

Risk calculators and risk factors for Teratoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Classification

  • The World Health Organization has classified CNS GCTs into germinomas and the following nongerminomatous germ cell tumor (NGGCT) groups:[1]
  • Choriocarcinoma.
  • Embryonal carcinoma.
  • Mixed germ cell tumor.
  • Teratoma.
  • Immature.
  • Mature.
  • Teratoma with malignant transformation.
  • Yolk sac tumor.
  • Childhood Extracranial Germ Cell Tumors classification
  • 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[2][3] Childhood extracranial GCTs can be divided into the following two types:
  • Gonadal.
  • Extragonadal.
  • 2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells.Childhood extracranial GCTs are broadly classified as the following:
  • Mature teratomas.
  • Immature teratomas.
  • Malignant GCTs.
  • 3. GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types:
  • Germinoma.
  • Germinoma.
  • Dysgerminoma (ovary).
  • Seminoma (testis).
  • Nongerminoma.
  • Teratoma (mature and immature).
  • Yolk sac tumor (endodermal sinus tumor).
  • Choriocarcinoma.
  • Embryonal carcinoma.
  • Gonadoblastoma.
  • Mixed GCT
  • 4. Pediatric GCT Biology
  • The following biologically distinct subtypes of GCTs are found in children and adolescents:
  • Testicular GCTs.
  • Ovarian GCTs.
  • Extragonadal extracranial GCTs.

References

  1. Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N; et al. (1997). "Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases". J Neurosurg. 86 (3): 446–55. doi:10.3171/jns.1997.86.3.0446. PMID 9046301.
  2. Dehner LP (1983). "Gonadal and extragonadal germ cell neoplasia of childhood". Hum Pathol. 14 (6): 493–511. PMID 6343221.
  3. McIntyre A, Gilbert D, Goddard N, Looijenga L, Shipley J (2008). "Genes, chromosomes and the development of testicular germ cell tumors of adolescents and adults". Genes Chromosomes Cancer. 47 (7): 547–57. doi:10.1002/gcc.20562. PMID 18381640.

Linked-in.jpg