Periodic fever, aphthous stomatitis, pharyngitis and adenitis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is a medical condition, typically starting in young children, in which high fever occurs periodically at intervals of about 3-5 weeks, frequently accompanied by aphthous ulcers, pharyngitis and/or adenitis. The syndrome was described in 1987 and named two years later.[1][2][3]

Signs and symptoms

The key symptoms of PFAPA are those in its name: periodic high fever at intervals of about 3-5 weeks, as well as aphthous ulcers, pharyngitis and/or adenitis. In between episodes, and even during the episodes, the children appear healthy.[3]

Cause

PFAPA is frequently discussed together with other periodic fever syndromes, but it is unknown whether the cause is primarily genetic or due to an initial infection.[3]

Treatment

A possible treatment for PFAPA is a single dose of prednisone (2 mg per kg body mass) at the beginning of each fever episode. The single dose usually terminates the fever within several hours. However, in some children, prednisone causes the fever episodes to occur more frequently (and more regularly).[2]

Prognosis

According to present research, PFAPA does not lead to other diseases and spontaneously resolves as the child gets older, with no long term effects.[2]


References

  1. Thomas, Kenneth Tyson (1999). "Periodic fever syndrome in children". Journal of Pediatrics. Mosby, Inc. 135: 1–5. Retrieved 2008-03-07. Unknown parameter |coauthors= ignored (help)
  2. 2.0 2.1 2.2 Padeh, Shai (1999). "Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: Clinical characteristics and outcome". Journal of Pediatrics. Mosby, Inc. 135: 98–101. Retrieved 2008-03-07. Unknown parameter |coauthors= ignored (help)
  3. 3.0 3.1 3.2 Long, Sarah S. (1999). "Syndrome of Periodic Fever, Aphthous stomatitis, Pharyngitis, and Adenitis (PFAPA) - What it isn't. What is it?". Journal of Pediatrics. Mosby, Inc. 135: 1–5. Retrieved 2008-03-07.

de:PFAPA-Syndrom


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