Difference between revisions of "Medullary thyroid cancer biopsy"

Jump to: navigation, search
Line 2: Line 2:
 
{{Medullary thyroid cancer}}
 
{{Medullary thyroid cancer}}
 
{{CMG}}; {{AE}} {{Ammu}}
 
{{CMG}}; {{AE}} {{Ammu}}
==Overview==
+
==Gallery==
On biopsy, medullary thyroid cancer is characterized by interstitial edema and coarse calcifications.
 
==Key Biopsy Findings in Medullary Thyroid Cancer==
 
===Microscopic Pathology===
 
* Microscopic features of medullary thyroid cancer is as follows:
 
====Cytoplasm and Nuclei====
 
:* Nested with delicate vascular septa
 
:* Trabecular cells
 
:* Tubular/glandular, pseudo-papillary cells
 
:* Polygonal to spindle to small cells
 
:* Amphophilic, somewhat granular cytoplasm
 
:* Interstitial edema
 
:* Vascular stroma may have amyloid deposits with fluffy appearing acellular eosinophilic material in the cytoplasm
 
:* Stroma can show hemorrhage, hyalinised collagen, oedema or metaplastic bone
 
:* Coarse calcification and psammoma bodies may be present
 
:* Nuclei with "neuroendocrine features"
 
:* Small, round nuclei.
 
:* Coarse chromatin (salt and pepper nuclei)
 
====Surrounding Thyroid====
 
:* +/-C-cell hyperplasia - seen with familial forms of medullary thyroid cancer
 
:* C cells (AKA parafollicular cell): abundant cytoplasm - clear/pale
 
==Biopsy Exams of Medullary Thyroid Cancer==
 
 
<gallery>
 
<gallery>
 
Image:Medullary thyroid carcinoma - low mag.jpg| Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
 
Image:Medullary thyroid carcinoma - low mag.jpg| Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology

Revision as of 16:24, 21 August 2019

Medullary thyroid cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Medullary thyroid cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Medullary thyroid cancer biopsy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Medullary thyroid cancer biopsy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Medullary thyroid cancer biopsy

CDC on Medullary thyroid cancer biopsy

Medullary thyroid cancer biopsy in the news

Blogs on Medullary thyroid cancer biopsy

Directions to Hospitals Treating Medullary thyroid cancer

Risk calculators and risk factors for Medullary thyroid cancer biopsy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Gallery

References


Linked-in.jpg