Difference between revisions of "Hepatocellular adenoma MRI"

Jump to: navigation, search
(MRI)
Line 7: Line 7:
  
 
==MRI==
 
==MRI==
* The MR imgaing findings of hepatocellualar adenoma include;<ref>{{cite journal|doi=10.1594/ecr2013/C-2620}}</ref><ref name="DhingraFiel2014">{{cite journal|last1=Dhingra|first1=Sadhna|last2=Fiel|first2=M. Isabel|title=Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic Characteristics|journal=Archives of Pathology & Laboratory Medicine|volume=138|issue=8|year=2014|pages=1090–1097|issn=0003-9985|doi=10.5858/arpa.2013-0183-RA}}</ref><ref name="NaultParadis2017">{{cite journal|last1=Nault|first1=Jean-Charles|last2=Paradis|first2=Valérie|last3=Cherqui|first3=Daniel|last4=Vilgrain|first4=Valérie|last5=Zucman-Rossi|first5=Jessica|title=Molecular classification of hepatocellular adenoma in clinical practice|journal=Journal of Hepatology|volume=67|issue=5|year=2017|pages=1074–1083|issn=01688278|doi=10.1016/j.jhep.2017.07.009}}</ref><ref>{{Cite journal
+
* The [[magnetic resonance imaging|MR imgaing]] findings of [[hepatocellualar adenoma]] include;<ref>{{cite journal|doi=10.1594/ecr2013/C-2620}}</ref><ref name="DhingraFiel2014">{{cite journal|last1=Dhingra|first1=Sadhna|last2=Fiel|first2=M. Isabel|title=Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic Characteristics|journal=Archives of Pathology & Laboratory Medicine|volume=138|issue=8|year=2014|pages=1090–1097|issn=0003-9985|doi=10.5858/arpa.2013-0183-RA}}</ref><ref name="NaultParadis2017">{{cite journal|last1=Nault|first1=Jean-Charles|last2=Paradis|first2=Valérie|last3=Cherqui|first3=Daniel|last4=Vilgrain|first4=Valérie|last5=Zucman-Rossi|first5=Jessica|title=Molecular classification of hepatocellular adenoma in clinical practice|journal=Journal of Hepatology|volume=67|issue=5|year=2017|pages=1074–1083|issn=01688278|doi=10.1016/j.jhep.2017.07.009}}</ref><ref>{{Cite journal
 
  | author = [[Maarten G. Thomeer]], [[Mirelle Broker]], [[Joanne Verheij]], [[Michael Doukas]], [[Turkan Terkivatan]], [[Diederick Bijdevaate]], [[Robert A. De Man]], [[Adriaan Moelker]] & [[Jan N. IJzermans]]
 
  | author = [[Maarten G. Thomeer]], [[Mirelle Broker]], [[Joanne Verheij]], [[Michael Doukas]], [[Turkan Terkivatan]], [[Diederick Bijdevaate]], [[Robert A. De Man]], [[Adriaan Moelker]] & [[Jan N. IJzermans]]
 
  | title = Hepatocellular adenoma: when and how to treat? Update of current evidence
 
  | title = Hepatocellular adenoma: when and how to treat? Update of current evidence
Line 96: Line 96:
 
}}</ref><ref name="DharmanaSaravana-Bawan2017">{{cite journal|last1=Dharmana|first1=H.|last2=Saravana-Bawan|first2=S.|last3=Girgis|first3=S.|last4=Low|first4=G.|title=Hepatocellular adenoma: imaging review of the various molecular subtypes|journal=Clinical Radiology|volume=72|issue=4|year=2017|pages=276–285|issn=00099260|doi=10.1016/j.crad.2016.12.020}}</ref>
 
}}</ref><ref name="DharmanaSaravana-Bawan2017">{{cite journal|last1=Dharmana|first1=H.|last2=Saravana-Bawan|first2=S.|last3=Girgis|first3=S.|last4=Low|first4=G.|title=Hepatocellular adenoma: imaging review of the various molecular subtypes|journal=Clinical Radiology|volume=72|issue=4|year=2017|pages=276–285|issn=00099260|doi=10.1016/j.crad.2016.12.020}}</ref>
  
* From hyperintense to mildly hypointense relative to liver tissue on T1 weighted images. This heterogeneous appearance results from areas of high intensity due to fat and acute hemorrhage and low signal intensity area corresponding to necrosis or old hemorrhage or calcifications.
+
* From hyperintense to mildly hypointense relative to [[liver]] [[tissue]] on T1 weighted images. This [[heterogeneous]] appearance results from areas of high intensity due to [[fat]] and acute [[hemorrhage]] and low signal intensity area corresponding to [[necrosis]] or old [[hemorrhage]] or [[calcification|calcifications]].
* The hepatocellular adenoma in T2 weighted images are predominantly hyperintense relative to liver, although in the presence of necrosis and hemorrhage they can be heterogeneous with hyper and hypo attenuating signal.
+
* The [[hepatocellular adenoma]] in T2 weighted images are predominantly hyperintense relative to [[liver]], although in the presence of [[necrosis]] and [[hemorrhage]] they can be [[heterogeneous]] with hyper and hypo [[attenuation|attenuating]] signal.
* Dynamic postgodalinium show intense arterial phase enhancement with isointensity on portal phase and delayed images.
+
* Dynamic postgodalinium show intense [[artery|arterial]] phase enhancement with isointensity on portal phase and delayed images.
* Hepatocellular adenoma do not have a central scar so if a central scar enhances after godalinium is administered, the diagnosis of focal nodular hyperplasia is strongly favored.
+
* [[Hepatocellular adenoma]] do not have a central [[scar]] so if a central [[scar]] enhances after godalinium is administered, the [[diagnosis]] of [[focal nodular hyperplasia]] is strongly favored.
* A central scar has never been reported in hepatocellular adenomas.
+
* A central [[scar]] has never been reported in [[hepatocellular adenomas]].
* With the injection of hepatocellular specific contrast agent, godalinium benzyloxypropionictetraacetate (Gd-BOTA) there is usually no significant uptake.
+
* With the injection of [[hepatocyte|hepatocellular]] specific [[contrast]] agent, godalinium benzyloxypropionictetraacetate (Gd-BOTA) there is usually no significant uptake.
 
<gallery>
 
<gallery>
 
Axial_T1_out_of_phase_hepatic_adenoma.jpg|liver MRI show a large, subtle T2 hyperintense, well defined rounded lesion in the liver which demonstrates homogenous signal loss on T1 opposed phase scans.
 
Axial_T1_out_of_phase_hepatic_adenoma.jpg|liver MRI show a large, subtle T2 hyperintense, well defined rounded lesion in the liver which demonstrates homogenous signal loss on T1 opposed phase scans.

Revision as of 16:04, 15 January 2019

Hepatocellular adenoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hepatocellular adenoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hepatocellular adenoma MRI On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hepatocellular adenoma MRI

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hepatocellular adenoma MRI

CDC on Hepatocellular adenoma MRI

Hepatocellular adenoma MRI in the news

Blogs on Hepatocellular adenoma MRI

Directions to Hospitals Treating Hepatocellular adenoma

Risk calculators and risk factors for Hepatocellular adenoma MRI

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Cafer Zorkun, M.D., Ph.D. [2] Zahir Ali Shaikh, MD[3]

Overview

The MRI findings of hepatocellular adenoma include; from hyperintense to mildly hypointense relative to the liver tissue on T1 weighted images. On T2 weighted images they are predominantly hyperintense relative to the liver, whereas in the presence of necrosis and hemorrhage they can be heterogeneous with hyper or hypo attenuating signal. The central scar is on godalinium is not seen in hepatocellular adenoma. There is usually no significant uptake with injection of hepatocellular specific contrast agent, godalinium benzoyloxypropionictetraacetate (Gd-BOTA).

MRI

References

  1. . doi:10.1594/ecr2013/C-2620. Missing or empty |title= (help)
  2. Dhingra, Sadhna; Fiel, M. Isabel (2014). "Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic Characteristics". Archives of Pathology & Laboratory Medicine. 138 (8): 1090–1097. doi:10.5858/arpa.2013-0183-RA. ISSN 0003-9985.
  3. Nault, Jean-Charles; Paradis, Valérie; Cherqui, Daniel; Vilgrain, Valérie; Zucman-Rossi, Jessica (2017). "Molecular classification of hepatocellular adenoma in clinical practice". Journal of Hepatology. 67 (5): 1074–1083. doi:10.1016/j.jhep.2017.07.009. ISSN 0168-8278.
  4. Maarten G. Thomeer, Mirelle Broker, Joanne Verheij, Michael Doukas, Turkan Terkivatan, Diederick Bijdevaate, Robert A. De Man, Adriaan Moelker & Jan N. IJzermans (2016). "Hepatocellular adenoma: when and how to treat? Update of current evidence". Therapeutic advances in gastroenterology. 9 (6): 898–912. doi:10.1177/1756283X16663882. PMID 27803743. Unknown parameter |month= ignored (help)
  5. L. Arrive, J. F. Flejou, V. Vilgrain, J. Belghiti, D. Najmark, M. Zins, Y. Menu, J. M. Tubiana & H. Nahum (1994). "Hepatic adenoma: MR findings in 51 pathologically proved lesions". Radiology. 193 (2): 507–512. doi:10.1148/radiology.193.2.7972769. PMID 7972769. Unknown parameter |month= ignored (help)
  6. Massimo Roncalli, Amedeo Sciarra & Luca Di Tommaso (2016). "Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma". Clinical and molecular hepatology. 22 (2): 199–211. doi:10.3350/cmh.2016.0101. PMID 27189732. Unknown parameter |month= ignored (help)
  7. Matthanja Bieze, Jacomina W. van den Esschert, C. Yung Nio, Joanne Verheij, Johannes B. Reitsma, Valeska Terpstra, Thomas M. van Gulik & Saffire S. K. S. Phoa (2012). "Diagnostic accuracy of MRI in differentiating hepatocellular adenoma from focal nodular hyperplasia: prospective study of the additional value of gadoxetate disodium". AJR. American journal of roentgenology. 199 (1): 26–34. doi:10.2214/AJR.11.7750. PMID 22733890. Unknown parameter |month= ignored (help)
  8. Andrei S. Purysko, Erick M. Remer, Christopher P. Coppa, Nancy A. Obuchowski, Erika Schneider & Joseph C. Veniero (2012). "Characteristics and distinguishing features of hepatocellular adenoma and focal nodular hyperplasia on gadoxetate disodium-enhanced MRI". AJR. American journal of roentgenology. 198 (1): 115–123. doi:10.2214/AJR.11.6836. PMID 22194486. Unknown parameter |month= ignored (help)
  9. Sheela Agarwal, Jorge M. Fuentes-Orrego, Thomas Arnason, Joseph Misdraji, Kartik S. Jhaveri, Mukesh Harisinghani & Peter F. Hahn (2014). "Inflammatory hepatocellular adenomas can mimic focal nodular hyperplasia on gadoxetic acid-enhanced MRI". AJR. American journal of roentgenology. 203 (4): W408–W414. doi:10.2214/AJR.13.12251. PMID 25055198. Unknown parameter |month= ignored (help)
  10. Maarten G. Thomeer, Francois E. Willemssen, Katharina K. Biermann, Haroun El Addouli, Rob A. de Man, Jan N. Ijzermans & Roy S. Dwarkasing (2014). "MRI features of inflammatory hepatocellular adenomas on hepatocyte phase imaging with liver-specific contrast agents". Journal of magnetic resonance imaging : JMRI. 39 (5): 1259–1264. doi:10.1002/jmri.24281. PMID 23897798. Unknown parameter |month= ignored (help)
  11. Heqing Wang, Chun Yang, Shengxiang Rao, Yuan Ji, Jing Han, Ruofan Sheng & Mengsu Zeng (2018). "MR imaging of hepatocellular adenomas on genotype-phenotype classification: A report from China". European journal of radiology. 100: 135–141. doi:10.1016/j.ejrad.2018.01.023. PMID 29496071. Unknown parameter |month= ignored (help)
  12. Dharmana, H.; Saravana-Bawan, S.; Girgis, S.; Low, G. (2017). "Hepatocellular adenoma: imaging review of the various molecular subtypes". Clinical Radiology. 72 (4): 276–285. doi:10.1016/j.crad.2016.12.020. ISSN 0009-9260.

Linked-in.jpg