Sandbox MWH

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Subtypes Explanation
Relapsing remitting
Secondary progressive
  • Patient with long term RRMS can switch to secondary relapsing multiple sclerosis (SPMS) when the neurological symptoms progressively worsen between the attacks
Primary progressive
Progressive relapsing


Table 1: A few milestones in narcolepsy research and therapy 1877 First description in the medical literature (100) 1880 Gelineau called the disorder “narcolepsy” (28) 1902 Loewenfeld coined the term “cataplexy” (53) 1935 First use of amphetamines in the treatment of narcolepsy (87) 1960 Description of Sleep Onset REM periods in a narcoleptic subject (99) 1970 Description of the Multiple Latency Test (15, 90) 1973 First report of a narcoleptic dog (47, 72) 1983 Association of narcolepsy with HLA-DR2 (37) 1985 Monoaminergic and cholinergic imbalance in narcolepsy (7, 80) 1992 Association of narcolepsy with HLA-DQB1*0602 (56, 63) 1998 Identification of hypocretins/orexins and their receptors (18, 93) 1999 Hypocretin mutations cause narcolepsy in mice and dogs (16, 51) 2000 Human narcolepsy is also associated with an hypocretin deficiency (81)