Ovarian germ cell tumor laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Monalisa Dmello, M.B,B.S., M.D. [3]

Overview

An elevated concentration a-fetoprotein (AFP) and b-human chorionic gonadotrophin (b-hCG) are diagnostic of malignant ovarian germ cell tumors.

Ovarian germ cell tumor Laboratory Findings

An elevated concentration a-fetoprotein (AFP) and b-human chorionic gonadotrophin (b-hCG) are diagnostic of malignant ovarian germ cell tumors.[1]

The tumor marker associated with ovarian germ cell tumor subtypes are as follows:[2]

Ovarian germ cell tumor subtype Tumor markers expressed
Dysgerminoma
Embryonal carcinoma
Endodermal sinus tumor or yolk sac tumors
Polyembryoma
Teratoma
Choriocarcinoma

Mature teratoma

Immature teratoma

  • Immature teratoma is associated with elevated AFP in one third of the cases.[5]

Dysgerminoma

Embryonal carcinoma

Endodermal sinus tumor

Polyembryoma

Non-gestational choriocarcinoma

References

  1. Pectasides, D.; Pectasides, E.; Kassanos, D. (2008). "Germ cell tumors of the ovary". Cancer Treatment Reviews. 34 (5): 427–441. doi:10.1016/j.ctrv.2008.02.002. ISSN 0305-7372.
  2. Ovary: Germ cell tumors. http://atlasgeneticsoncology.org/Tumors/OvarianGermCellID5067.html. URL Accessed on November 10, 2015
  3. Yayla Abide, Çiğdem; Bostancı Ergen, Evrim (2018). "Retrospective analysis of mature cystic teratomas in a single center and review of the literature". Journal of Turkish Society of Obstetric and Gynecology. 15 (2): 95–98. doi:10.4274/tjod.86244. ISSN 1307-699X.
  4. Chen C, Li JD, Huang H, Feng YL, Wang LH, Chen L (January 2008). "[Diagnostic value of multiple tumor marker detection for mature and immature teratoma of the ovary]". Ai Zheng (in Chinese). 27 (1): 92–5. PMID 18184473.
  5. Gershenson, David M. (2007). "Management of Ovarian Germ Cell Tumors". Journal of Clinical Oncology. 25 (20): 2938–2943. doi:10.1200/JCO.2007.10.8738. ISSN 0732-183X.
  6. Shaaban, Akram M.; Rezvani, Maryam; Elsayes, Khaled M.; Baskin, Henry; Mourad, Amr; Foster, Bryan R.; Jarboe, Elke A.; Menias, Christine O. (2014). "Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features". RadioGraphics. 34 (3): 777–801. doi:10.1148/rg.343130067. ISSN 0271-5333.
  7. 7.0 7.1 Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN (May 2003). "Pathology and classification of ovarian tumors". Cancer. 97 (10 Suppl): 2631–42. doi:10.1002/cncr.11345. PMID 12733128.
  8. Stein, Erica B.; Wasnik, Ashish P.; Sciallis, Andrew P.; Kamaya, Aya; Maturen, Katherine E. (2017). "MR Imaging–Pathologic Correlation in Ovarian Cancer". Magnetic Resonance Imaging Clinics of North America. 25 (3): 545–562. doi:10.1016/j.mric.2017.03.004. ISSN 1064-9689.
  9. Low, Jeffrey J.H.; Ilancheran, Arunachalam; Ng, Joseph S. (2012). "Malignant ovarian germ-cell tumours". Best Practice & Research Clinical Obstetrics & Gynaecology. 26 (3): 347–355. doi:10.1016/j.bpobgyn.2012.01.002. ISSN 1521-6934.

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