Medullary thyroid cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Medullary thyroid cancer may be classified according to the mode of occurrence into 2 groups: sporadic medullary thyroid cancer and inherited medullary thyroid cancer.

Classification

  • Medullary thyroid cancer may be classified according to the mode of occurrence into 2 groups: sporadic medullary thyroid cancer and inherited medullary thyroid cancer.
  • Sporadic medullary thyroid cancer[1][2]
  • Sporadic medullary thyroid cancer (75% of the cases)
  • Inherited medullary thyroid cancer (25% of the cases)
  • Medullary thyroid cancer may be classified according to histologic variants into:[3]
    • Papillary or pseudopapillary due to the presence of papillary structures or artifactual structures resembling papillae.
    • Glandular
    • Giant cells
    • Spindle cell
    • Small cell and Neuroblastoma-like
    • Paraganglioma-like
    • Onchocytic cell
    • Clear cell
    • Angiosarcoma-like
    • Squamous cell
    • Melanin-producing
    • Amphicrine

Reference

  1. Thyroid Cancer Cancer.gov (2015). http://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq#link/stoc_h2_2- Accessed on October, 29 2015
  2. Raue, Friedhelm; Frank-Raue, Karin (2015). "Epidemiology and Clinical Presentation of Medullary Thyroid Carcinoma". 204: 61–90. doi:10.1007/978-3-319-22542-5_3. ISSN 0080-0015.
  3. DeLellis, Ronald (2004). Pathology and genetics of tumours of endocrine organs. Lyon: IARC Press. ISBN 92-832-2416-7.

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