Hepatocellular adenoma medical therapy

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Hepatocellular adenoma Microchapters


Patient Information


Historical Perspective




Differentiating Hepatocellular adenoma from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings



Echocardiography and Ultrasound

CT scan


Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hepatocellular adenoma medical therapy On the Web

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Most cited articles

Review articles

CME Programs

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Blogs on Hepatocellular adenoma medical therapy

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Risk calculators and risk factors for Hepatocellular adenoma medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]


There is no specific medical therapy for hepatocellular adenoma. The wait-and-watch policy is recommended for hepatocellular adenomas < 5 cm following cessation of offending drugs (OCPs) with no further growth detected. An annual follow-up with MRI or ultrasound is scheduled for female patients untill menopause.

Medical Therapy


  1. Toso C, Majno P, Andres A, Rubbia-Brandt L, Berney T, Buhler L, Morel P, Mentha G (2005). "Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors". World J Gastroenterol. 11 (36): 5691–5. PMID 16237767.Full text
  2. Ault GT, Wren SM, Ralls PW, Reynolds TB, Stain SC (1996). "Selective management of hepatic adenomas". Am Surg. 62 (10): 825–9. PMID 8813164.
  3. Maarten G. Thomeer, Mirelle Broker, Joanne Verheij, Michael Doukas, Turkan Terkivatan, Diederick Bijdevaate, Robert A. De Man, Adriaan Moelker & Jan N. IJzermans (2016). "Hepatocellular adenoma: when and how to treat? Update of current evidence". Therapeutic advances in gastroenterology. 9 (6): 898–912. doi:10.1177/1756283X16663882. PMID 27803743. Unknown parameter |month= ignored (help)
  4. Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
  5. A. F. Mariani, A. S. Livingstone, R. V. Jr Pereiras, P. E. van Zuiden & E. R. Schiff (1979). "Progressive enlargement of an hepatic cell adenoma". Gastroenterology. 77 (6): 1319–1325. PMID 499719. Unknown parameter |month= ignored (help)
  6. P. H. Andersen & J. T. Packer (1976). "Hepatic adenoma. Observations after estrogen withdrawal". Archives of surgery (Chicago, Ill. : 1960). 111 (8): 898–900. PMID 182106. Unknown parameter |month= ignored (help)
  7. S. Kay (1977). "Nine year follow-up of a case of benign liver cell adenoma related to oral contraceptives". Cancer. 40 (4): 1759–1760. PMID 198104. Unknown parameter |month= ignored (help)
  8. P. Aseni, C. V. Sansalone, C. Sammartino, F. D. Benedetto, G. Carrafiello, A. Giacomoni, C. Osio, M. Vertemati & D. Forti (2001). "Rapid disappearance of hepatic adenoma after contraceptive withdrawal". Journal of clinical gastroenterology. 33 (3): 234–236. PMID 11500616. Unknown parameter |month= ignored (help)
  9. H. Buhler, M. Pirovino, A. Akobiantz, J. Altorfer, M. Weitzel, E. Maranta & M. Schmid (1982). "Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use". Gastroenterology. 82 (4): 775–782. PMID 6277724. Unknown parameter |month= ignored (help)
  10. B. Heeringa & A. Sardi (2001). "Bleeding hepatic adenoma: expectant treatment to limit the extent of liver resection". The American surgeon. 67 (10): 927–929. PMID 11603546. Unknown parameter |month= ignored (help)