Chromogranin

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chromogranin A (parathyroid secretory protein 1)
Identifiers
SymbolCHGA
Entrez1113
HUGO1929
OMIM118910
RefSeqNM_001275
UniProtP10645
Other data
LocusChr. 14 q32
chromogranin B (secretogranin 1)
Identifiers
SymbolCHGB
Alt. symbolsSCG1
Entrez1114
HUGO1930
OMIM118920
RefSeqNM_001819
UniProtP05060
Other data
LocusChr. 20 pter-p12
secretogranin II (chromogranin C)
Identifiers
SymbolSCG2
Entrez7857
HUGO10575
OMIM118930
RefSeqNM_003469
UniProtP13521
Other data
LocusChr. 2 q35-q36

The chromogranin/secretogranin (granins) are a family of regulated secretory proteins ubiquitously found in the cores of amine and peptide hormone and neurotransmitter dense-core secretory vesicles, and consist of several independent proteins:

Four other proteins (secretogranin III-VI) are also proposed to belong to the granins on the basis of their physico-chemical properties.

Granins function as pro-hormones, giving rise to an array of peptide fragments for which autocrine, paracrine, and endocrine activities have been demonstrated in vitro and in vivo.

The intracellular biochemistry of granins includes binding of Ca2+, ATP and catecholamines (epinephrine, norepinephrine) within the hormone storage vesicle core.

There is evidence that CgA, and perhaps other granins, regulate the biogenesis of dense-core secretory vesicles in neuroendocrine cells.


External links

de:Chromogranine


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