Atherosclerosis historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Historical Perspective

Discovery

  • Atherosclerosis was recognized during the 19th century.
  • In 1910 Windaus reported that atherosclerotic plaque contained cholestrol.
  • The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
  • In 1939, Carl Muller was the first to discover the association between genetic and the development of atherosclerosis.[1]


Landmark Events in the Development of Treatment Strategies

  • In 1959 Triparanol was the first cholestrol-lowering agent that introduced in US.But in 1960 because of serious side effects it was whithdrawn from the market.
  • A canadian pathologist Rudolf Altschul was discovered nicotinic acid in 1955 ,and in 1958 England synthesized Clofibrate.
  • Akiro Endo (japanes}in 1970 discovered Hmg-coAreductase inhibitors.[1]

Impact on Cultural History

Famous Cases

The following are a few famous cases of [disease name]:

References

  1. 1.0 1.1 Endo A (2010). "A historical perspective on the discovery of statins". Proc Jpn Acad Ser B Phys Biol Sci. 86 (5): 484–93. doi:10.2183/pjab.86.484. PMC 3108295. PMID 20467214.



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