(S,S)-butanediol dehydrogenase

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In enzymology, a (S,S)-butanediol dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

(S,S)-butane-2,3-diol + NAD+ acetoin + NADH + H+

Thus, the two substrates of this enzyme are (S,S)-butane-2,3-diol and NAD+, whereas its 3 products are acetoin, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S,S)-butane-2,3-diol:NAD+ oxidoreductase. Other names in common use include L-butanediol dehydrogenase, L-BDH, and L(+)-2,3-butanediol dehydrogenase (L-acetoin forming). This enzyme participates in butanoic acid metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Taylor MB and Juni E (1960). "Stereoisomeric specificities of 2,3-butanediol dehydrogenase". Biochim. Biophys. Acta. 39: 448&ndash, 457.

External links

The CAS registry number for this enzyme class is 37250-14-9.

Gene Ontology (GO) codes